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Utilizing Open Source Research Data to Combat Neglected Diseases

This award would partially fund Phase I of a Medicinal Chemistry Cheminformatics Concentration Track for students enrolled in a school of pharmacy. In Phase I students will learn to use literature (NLM) and open data sources (DNDi/WHO) to curate and analyze early drug discovery chemical data focusing on neglected diseases. Student outcomes will include mastery in the use of cheminformatics software (Optibrium/StarDrop™) for data management, data visualization and predictive calculations. Phase II will introduce students to the chemical synthesis of new drug leads based on their Phase I data. The synthetic steps and biological activity results of all compounds will be shared internationally via an open source electronic laboratory notebook (ELN). The impact of the proposal is three-fold: 1) increase health care personnel training in pharma-relevant informatics, 2) apply data management skills to curate analyze and use a cheminformatics database and 3) synthesize new chemical compounds aimed at treating neglected diseases. The diseases targeted are Leishmaniasis and American Trypanosomiasis.
Identify any specific population(s) this project will serve: 
Adults
Identify roles of participants this project will serve: 
Data resource or tool developer
Educator, college & post-grad
Health care provider
Library or information professional
Researcher
Student, college & post-grad
Funding Source: 
NER
Project Funding:
Federal Fiscal Year: 
2020
Funding Amount: 
$10000
Funding Period:
May 1, 2020 to Apr 30, 2021
Project Status:
Awarded