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Using Data to Improve Clinical Patient Outcomes

Resources Cited by Presenters

David C Kaelber, MD, PhD, MPH: Using Clinical Data to Improve Clinical Patient Outcomes – Case Studies from the MetroHealth System

ML Hanson, PW Gunn, and DC Kaelber. Underdiagnosis of Hypertension in Children and Adolescents. Journal of the American Medical Association. 298(8):874-9. 2007. PMID: 17712071.

Bar-shain D, P Stager, A Runkle, J Leon, and DC Kaelber. Direct Messaging to Parent/Guardians to Improve Adolescent Immunizations. Journal of Adolescent Health. 2015. PMID: 25863550.

Fitch K, Pyenson BS, and Iwaasaki K. Medical Claim Cost Impact of Improved Diabetes Control for Medicare and Commercially Insured Patients with Type 2 Diabetes. Journal of Managed Care Pharmacy. 19(8):609-620. 2013. PMID: 24074007.


Christopher Longhurst, MD, MS: Evidence-based Medicine in the EMR Era: Bringing Big Data to the Bedside

Frankovich J, Longhurst CA, Sutherland SM. Evidence-based medicine in the EMR era. N Engl J Med. 2011 Nov 10;365(19):1758-9. doi: 10.1056/NEJMp1108726. Epub 2011 Nov 2. PubMed PMID: 22047518.

Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ; TRIPICU Investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators Network. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med. 2007 Apr 19;356(16):1609-19. PubMed PMID: 17442904.

Adams ES, Longhurst CA, Pageler N, Widen E, Franzon D, Cornfield DN. Computerized physician order entry with decision support decreases blood transfusions in children. Pediatrics. 2011 May;127(5):e1112-9. doi: 10.1542/peds.2010-3252. Epub 2011 Apr 18. PubMed PMID: 21502229.

Pageler NM, Franzon D, Longhurst CA, Wood M, Shin AY, Adams ES, Widen E, Cornfield DN. Embedding time-limited laboratory orders within computerized provider order entry reduces laboratory utilization. Pediatr Crit Care Med. 2013 May;14(4):413-9. doi: 10.1097/PCC.0b013e318272010c. PubMed PMID: 23439456.

Longhurst C, Turner S, Burgos AE. Development of a Web-based decision support tool to increase use of neonatal hyperbilirubinemia guidelines. Jt Comm J Qual Patient Saf. 2009 May;35(5):256-62. PubMed PMID: 19480378.

Patel SJ, Longhurst CA, Lin A, Garrett L, Gillette-Arroyo J, Mark JD, Wood MS, Sharek PJ. Integrating the home management plan of care for children with asthma into an electronic medical record. Jt Comm J Qual Patient Saf. 2012 Aug;38(8):359-65. PubMed PMID: 22946253.

Pageler NM, Longhurst CA, Wood M, Cornfield DN, Suermondt J, Sharek PJ, Franzon D. Use of electronic medical record-enhanced checklist and electronic dashboard to decrease CLABSIs. Pediatrics. 2014 Mar;133(3):e738-46. doi: 10.1542/peds.2013-2249. Epub 2014 Feb 24. PubMed PMID: 24567021; PubMed Central PMCID: PMC3934335.

Palma JP, Keller H, Godin M, Wayman K, Cohen RS, Rhine WD, Longhurst CA. Impact of an EMR-Based Daily Patient Update Letter on Communication and Parent Engagement in a Neonatal Intensive Care Unit. J Particip Med. 2012 Dec 31;4. pii: e33. PubMed PMID: 23730532; PubMed Central PMCID: PMC3666033.

Longhurst CA, Harrington RA, Shah NH. A 'green button' for using aggregate patient data at the point of care. Health Aff (Millwood). 2014 Jul;33(7):1229-35. doi: 10.1377/hlthaff.2014.0099. PubMed PMID: 25006150.

Gallego B, Walter SR, Day RO, Dunn AG, Sivaraman V, Shah N, Longhurst CA, Coiera E. Bringing cohort studies to the bedside: framework for a 'green button' to support clinical decision-making. J Comp Eff Res. 2015 May 11:1-7. PubMed PMID: 25959863.

Faden RR, Kass NE, Goodman SN, Pronovost P, Tunis S, Beauchamp TL. An ethics framework for a learning health care system: a departure from traditional research ethics and clinical ethics. Hastings Cent Rep. 2013 Jan-Feb; Spec No:S16-27. doi: 10.1002/hast.134. PubMed PMID: 23315888.

Friedman CP, Wong AK, Blumenthal D. Achieving a nationwide learning health system. Sci Transl Med. 2010 Nov 10;2(57):57cm29. doi: 10.1126/scitranslmed.3001456. PubMed PMID: 21068440.

Kohane IS, Drazen JM, Campion EW. A glimpse of the next 100 years in medicine. N Engl J Med. 2012 Dec 27;367(26):2538-9. doi: 10.1056/NEJMe1213371. PubMed PMID: 23268669.


Nick Meo, MD: The Triple Aim at the Frontlines: Lessons from a VA Experience in Using Data to Drive Change

Veterans Health Administration, Department of Veterans Affairs. Blueprint for Excellence. September  21, 2014. Available from: (link is external).

Fihn SD, Francis J, Clancy C, Nielson C, Nelson K, Rumsfeld J, Cullen T, Bates J, Graham GL. Insights from advanced analytics at the Veterans Health Administration. Health Aff (Millwood). 2014 Jul;33(7):1203-11. doi: 10.1377/hlthaff.2014.0054. PubMed PMID: 25006147.

Wang L, Porter B, Maynard C, Evans G, Bryson C, Sun H, Gupta I, Lowy E, McDonell M, Frisbee K, Nielson C, Kirkland F, Fihn SD. Predicting risk of hospitalization or death among patients receiving primary care in the Veterans Health Administration. Med Care. 2013 Apr;51(4):368-73. doi: 10.1097/MLR.0b013e31827da95a. PubMed PMID: 23269113.   

Other Resources


Use of Clinical Big Data to Inform Precision Medicine (link is external)
In this National Library of Medicine Informatics Lecture Series presentation, Joshua Denny, MD, from Vanderbilt University, speaks about precision medicine in his talk, “Use of Clinical Big Data to Inform Precision Medicine” on November 4, 2015.  

Health Information Exchange, AHRQ Evidence Report/Technology Assessment No. 220 (link is external)
This report is intended to help health care decision makers—patients and clinicians, health system leaders, and policymakers, among others—make well informed decisions and thereby improve the quality of health care services. This review broadly identifies, summarizes, and synthesizes the available research about health information exchange.

Using Big Data to Transform Care, Health Affairs, Volume 33, Issue 7 (link is external)
The explosion of electronic health data has segued into big data that may have the power to transform healthcare as we know it. Experts explore several facets of this transformation in articles and position papers inside this issue.

Your Heart is Big Data (link is external)
University of Washington Tacoma’s Center for Data Science collaborates with MultiCare and Microsoft to improve outcomes for hospital patients with heart disease.

Using Big Data to Make Wiser Medical Decisions (link is external)
John Halamka MD, Chief Information Officer at Beth Israel Deaconess Medical Center in Boston, describes three uses of big data that have helped patients, including himself and his family.

How Successful Hospitals Start to Tackle Big Data Analytics (link is external)
This Health IT Analytics article explores lessons learned by institutions who are achieving positive results—improvement in patient care--through their big data analytics strategies.