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Patient-Centered Outcomes Research Institute Seeks Applications to Fund $120 Million in Comparative Clinical Effectiveness Research in 2012

DENVER, Colo. (May 22, 2012) — The Patient-Centered Outcomes Research Institute (PCORI) today released its first primary research funding announcements to support comparative clinical effectiveness research that will give patients and those who care for them the ability to make better-informed health care decisions.

PCORI will award $120 million this year for innovative projects that effectively incorporate patients and stakeholders in research teams and address the areas of focus of PCORI’s National Priorities for Research and Research Agenda. PCORI previously announced the approval of 50 Pilot Project Program awards, totaling $30 million over two years, to researchers in 24 states and the District of Columbia.

“Today marks a major milestone in our work as we build a portfolio of patient-centered research that will provide patients and those who care for them better information about health care decisions they face,” said PCORI Executive Director Joe Selby, M.D., M.P.H. “Our funding announcements reflect PCORI’s commitment to a patient-centered research agenda, emphasizing the inclusion of patients and caregivers at all stages of the research.”

The PCORI Funding Announcements (PFAs) make clear that successful applicants must have research teams with patients, caregivers, and practicing clinicians actively engaged throughout the process, from generating research questions to conducting research and using the results to understand and address patient needs. This requirement helps ensure that the research remains true to the interests of the patient populations that will be affected by it.

Applications will be evaluated for alignment with eight PCORI review criteria that arise from PCORI’s authorizing legislation. These include: impact or burden of the condition(s) being studied; innovativeness of the research proposal and its potential to impact care practices and improve outcomes; inclusiveness of different populations; patient-centeredness of the research question, choices of outcomes, and strategies for inclusion of patients and stakeholders in the research; potential for the research to improve the efficiency of health care; use of rigorous study design and analytic methods; composition and experience of the research team; and efficient use of research resources.

“Our priorities and agenda capture the broad areas where more research is needed,” said PCORI Board Chair Eugene Washington, M.D., M.Sc. “We look forward to continuing our work with patients and stakeholders to refine and define our areas of focus to make the agenda more specific over time.”



The Patient-Centered Outcomes Research Institute (PCORI) is an independent, non-profit organization created by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better-informed health care decisions. PCORI is committed to continuously seeking input from a broad range of stakeholders to guide its work. More information is available at

One Response to “Patient-Centered Outcomes Research Institute Seeks Applications to Fund $120 Million in Comparative Clinical Effectiveness Research in 2012”

  1. Annette Fitzpatrick Says:

    Hi. Can PCORI applications be on a global scale, that is, in countries outside of the US if the PI’s institution is in the US? I am wondering about the huge need for patient-centered research in developing countries.

    Thank you.