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eScience is defined broadly as big computational science, team science and networked science. It includes all scientific domains, as well as biomedicine and social sciences that share research approaches with the sciences. eScience is about global collaboration in key areas of science and the next generation of infrastructure that it will enable and support.

Researchers working within eScience could require access to very large data collections and large scale computing resources in order to share their data with others, or they could require access to smaller data collections where a number of different researchers need to be involved. The principle idea surrounding eScience is that it is collaborative in nature, providing opportunities for researchers and scientists to share their data; discuss new avenues for research; and work together to produce better results. Librarians can contribute to eScience by planning projects, programs and services, and preparing the library workforce to work in eScience disciplines such as data management, data sharing and data education.