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NLM Announces the Release of a New Free Resource: LiverTox!

LiverTox is a freely available website that provides up-to-date, comprehensive, and unbiased information about drug-induced liver injury caused by prescription and nonprescription drugs, herbals, and dietary supplements.LiverTox website The LiverTox website provides a comprehensive resource for physicians and their patients, and for clinical academicians and researchers to identify basic and clinical questions to be answered, and to chart optimal ways to diagnose and control drug-induced liver injury.

LiverTox provides a searchable database of about 700 medications available in the United States. Over the next few years, another 300 drugs will be added. Drug-induced liver injury is the leading cause of acute liver failure in this country. Some drugs directly damage the liver, while others cause damage indirectly or by an allergic reaction. LiverTox is a joint effort within the National Institutes of Health (NIH), involving the Liver Disease Research Branch of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Division of Specialized Information Services (SIS) of NLM.

LiverTox has three major components:

  • Introduction and overview of drug induced liver injury;
  • Specific drug records that provide concise data on the hepatotoxicity of medications, herbals and dietary supplements; and
  • Case submission registry that allows users to provide comments about the LiverTox database, and submit clinical cases to the LiverTox website and U.S. Food and Drug Administration’s MedWatch program, used to monitor product safety.

LiverTox developers work with outside experts in drug-induced liver disease, as well as with specialists in arthritis, cancer, diabetes, infectious diseases, and other conditions. The finished website has also been reviewed by FDA and pharmaceutical industry experts on liver-related complications. The database will be updated regularly with information about drug-induced liver injury, as well as with new drugs and concepts. For more information about LiverTox, visit the About Us section.

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