Request for Information (RFI) on FedBizOpps: https://www.fbo.gov/index?s=opportunity&mode=form&id=86fdd4313f3bc1ecde69cad3536118ab&tab=core&_cview=0
The National Institute on Aging (NIA) and National Institutes of Health (NIH) Library propose to create a data repository, Alzheimer’s Preclinical Efficacy Database or AlzPED to mitigate the challenges of animal model studies and increase the translation of AD therapies to the clinic. This database will contain information relating to the preclinical testing of candidate therapeutic agents in Alzheimer’s disease (AD) animal models. More specifically, within the scope of this project the NIA is creating a web-based portal for housing, sharing and mining of data relating to the preclinical testing of therapeutic agents in AD animal models. This portal will house experimental details, designs and, analyses of both positive and negative data. The database will be broadly available to scientists from academic centers, industry, disease-focused foundations and the lay public.
Data will be gleaned from at least two sources; 1) the scientific literature; 2) directly from researchers. It will be populated through a public submission form and through subject matter expert curation of relevant literature. Content will include information on the animal models, study design, primary and secondary outcome measures, statistical plan, therapeutic agents (e.g., drugs, biologics), formulation, and route of administration, dose and duration of treatment, data analyses and results.